Peptic & Duodenal Ulcers Pains Treatment Tablet
Observing the diet, one or two tablets before every meal for 4 to 6 weeks.
Gastrodin tablet can be prescribed solely or with anti-acid medications.
Each Gastrodin tablet contains 400 mg of glycyrrhiza glabra root extract (whose glycyrrhizin content is reduced as far as possible) and extract of calendula off. flowers as well as althaea off root powder.
|Pharmacology and Mechanism of Action||
Recent analyses have shown that the extracts of the abovementioned herbs contain components affecting gastritis and peptic ulcers of stomach and deudenum;The most crucial ones being flavonoids, saponosides, and its mucilage compounds. Effect mechanism of gastrodin is a series of mechanism related to its effective matters. Anti-secretion effect of gastric acid and anti-ulcer effect of Glycyrrhiza glabra might be associated with stoppage of action between mucosal receptors and release of acetyl choline of vagus nerves. In addition, it reinforces the mucous barrier against impact of gastric acid via influencing the chemical composition of stomach mucus. Effect mechanism of flavonoids of Glycyrrhiza glabra and calendula is also expressed based on anti-inflammatory effects of flavonoids that can prevent from release of histamines, and additionally, leave other impacts on them such as stabilization of lysosome membrane and influence on capillary permeability and strength. Mucilage of Althaea off. also has protective effects on digestive system mucus.
Intake of total root and extract in the long term would result in elevated blood pressure and occurrence of mineralocorticoid symptoms due to presence of high glycyrrhizin content. For the same reason, to minimize this side effect, gastrodin tablet is made of essence of the Glycyrrhiza glabra with lowest amount of glycyrrhizin.
|Interactions||Gastrodin has interaction with medicines which can lower potassium such as Thiazide duretics and laxatives that contain senna.|