IBS symptoms Treatments Oral Drop
|Indications||Treating symptoms of irritable bowel syndrome
Drop - 15 ml
|Composition||Essential oil of Zataria multiflora
|Suggested Use||20 drops every 8 hours with plenty of water|
Thymol and carvacrol
|Standardized||Based on at least 4.4–7 mg thymol in each ml of product|
|Pharmacology and Mechanism of Action||
Thyme has lots of valuable effects. This plant is a perfect respiratory system disinfectant and is useful for the all respiratory infections and protects throat and oral cavity from infections. Thyme can be used as an inhaler in lung, throat and nose infections or be used as a mouth wash and gargle.
0.1% of thyme essential oil presence in the toothpaste prevents mouth and gingival infections by its antibacterial effect. Thyme oil delays the meat decay; so in process of meat packaging before freezing and during traveling that use of refrigerator is impossible, thyme can be used in order to prevent meat decomposition.
Thyme disinfects the intestine and it has spectacular effects in stomach infections, it is able to remove intestine worms (roundworm, tapeworm, and fluke). Recent studies results show thyme oil slow down the growth rate of bacteria and protect Petri dish from contamination for 3 days.
Thyme oil is a good gastrointestinal stimulant and it is useful for the one with the gastrointestinal discomfort and for recovery period and it is appetite stimulant.
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders which is characterized by abdominal pain and/or discomfort together with change in bowel habits like intermittent diarrhea and constipation.
One of the diagnostic methods for IBS is Rome III criteria that include: recurrent abdominal pain or discomfort at least 3 days a month in past 3 months with two or more of:
1-improvement with defecation; 2-Onset associated with change in frequency of stool; and 3- Onset associated with a change in form (appearance) of stool.
Under the Rome III criteria, IBS affect around 5-10% of population in both developed and developing countries and women are main victim of this disorder and maximum incidence is in third and forth decade of age.
Unfortunately, the available treatment options for IBS patients are limited which is partly due to the fact that its mechanism of action and etiology is not known properly.
Medicinal plants are commonly used to relieve the symptoms of IBS. Based on results of a prospective double blind, placebo-controlled, randomized study; after 4 weeks of therapy with capsules containing mint essential oil; 75% of the patients showed a >50% reduction in symptoms (compared with 38% in the placebo group). Comparing with the start of study, despite placebo group, in the group which was taking capsules with mint oil, 4 weeks after treatment has been started and 4 weeks after its finish, significant statistical reduction in symptoms were seen.
Avishan-e- shirazi (Zataria multiflora) is one of the native Iranian plants that is used in Iranian traditional folk remedies for its antiseptic, analgesic and carminative properties.
Investigations on laboratory animals show that Zataria multiflora essential oil extracted from leaves, dose dependently, in low concentration (0.5-16 µl/ml) prohibited Kcl related contractions in rat's ileum which is similar to the dicyclomine effects.
In a double blind, randomized, multi-center clinical trial; based on Manning criteria for IBS, effectiveness of Gastrolit oral drop were proved which were studied in 53 patients. According to the results of this study; after 2 weeks of treatment with 20 drops 3 times a day, Gastrolit drop was effective in all of IBS symptoms (p<0.002) and mostly the physicians and patients were satisfied with it.
|Contraindications||Thyroid disorders, pregnancy and lactation|
No side effects were reported by using appropriate amount and right way of consumption. However in the case of overdose or in sensitive people, thymol in the product can cause dizziness, headache, nausea, vomiting, asthenia, lowering the activity of heart, respiratory system and body temperature, which in these cases it should be quitted or consulted with the doctor
|Interactions||There were no reports of interactions|