Anti Depression Oral Drop

Anti Depression Oral Drop
  • Product Code: SJJ019
  • Availability: In Stock
Detailed Specifications
Indications Anti-depressants
Dosage form Drop - 30 ml with a dropper in carton box with brochure.
Composition Essential oil of Pelargonium roseum
Suggested Use Twice a day, each time 20 drops after meals with drinking.
Effective Ingredients Citronellol, geraniol, isomenthone
Standardized Based on presence of 0.98-1.32 mg carbohydrate, 5.4-6.6 mg citronellol and 4.9-5.9 mg 1,8 cineole per one gram of the product. 
Pharmacology and Mechanism of Action
Depression is one of the most common psychiatric disorders with 15-20 % prevalence that may result in decreased personal and social functioning and also loss of interest or pleasure and emotional pressure.
According to diagnostic criteria of DSM IV; major depressive disorders (MDD) is characterized by: depressed mood accompanied by sleep disturbances; loss of interest / pleasure; sense of guilty and feelings of worthlessness; loss of energy and fatigue; poor concentration and attention; weight/appetite changes; psychomotor changes and suicidal thought. For diagnosis of MDD, depressed mood or loss of interest /pleasure and 4 other symptoms, must last for at least 2 weeks and these symptoms shouldn’t be due to the death of a loved one. Depressive disorders are usually chronic and recurrent and about 70% of patient with one depressive attack will experience another one. Furthermore, when discontinuing an antidepressant, clinical surveillance must be continue according to each patient situation.
In the study of antidepressant efficacy of geranium essential oil in rats, oral administration of the oil with concentration of 0.5-2 percent decreased the immobility time in the forced- swim test (p<0.0001) and intra-peritoneal injection of 5 mg /kg reserpine ,18 hours before geranium oil prescription, significantly antagonized the decreasing impact of oral essential oil (concentration 1.5 percent).
These results approved the antidepressant effect of geranium oil and proposed that the antidepressant activity of geranium oil may be mediated through a presynaptic mechanism.
Furthermore, in a double-blind, randomized clinical trial, 81 patients 18 to 50 years of age with depression were randomly classified in three groups: fluoxetine capsule (20 mg/day) and placebo drop; geranium oral drop 10% (20 drops, twice daily) and placebo capsule; geranium oral drop 5% (20 drops, twice daily) and placebo capsule.
The study carried out in 12 weeks, and patients were visited at the initiation, every two weeks and at the end of the research with interview, clinical examination and Beck test. Results suggest that geranium drop 10% caused a considerable statistical decrease in scores of beck test in visit phases 3 and 4 (p<0.03), however, due to bad taste, failure rate in this group was considerably higher than other groups (p<0.001). Moreover, geranium drop 5% produced better effects than did fluoxetine, it's effect begins quicker than fluoxetine, and recovery percentage of geranium drop 5% reported 90.9% (whereas fluoxetine caused 71.4% recovery). Such difference was statistically significant. (p=0.05)

  • Pregnancy period
  • Children

Adverse Effects With the suggested dosage and appropriate administration, no adverse effect has been reported. In case of occurrence of any adverse reaction, including allergy, discontinue use and consult your physician.
No reported drug interaction. 

  • Keep out of the sight and reach of children.
  • Store your medicine at 15-30˚C, keep it in its original pack, away from light. The tube should be tightly closed.

  • ISO 17025
  • IR GMP
  • ISO 9001
  • I.R.I.FDO

  • ISO 10004
  • ISO 10668

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