Acute Cough Treatment Soft Capsule

Acute Cough Treatment Soft Capsule
  • Product Code: SVJ035
  • Availability: In Stock
Detailed Specifications
Adjuvant treatment for acute cough
Dosage form
30 Soft capsule - 40 mg 
  • Sweet fennel (Foeniculum vulgare)
  • Iranian thyme (Zataria multiflora)
Suggested Use Every 8 hours, take 1 Thymogel Oral Soft Capsule with a glass of lukewarm
Effective Ingredients Thymol, carvacrol, anethole and fenchone
Standardized Based on presence of 14-18 mg anethole and 5.4-6.6 mg thymol per soft capsule
Pharmacology and Mechanism of Action
The European Commission has approved the administration of thyme for cough and bronchitis. In the case of thymol and carvacrol, a broad spectrum of effects against bacteria involved in the infections of the upper respiratory tract has been observed. It is believed that thymol and carvacrol exert their antibacterial activity through complex formation with the proteins in the bacterial membrane. A synergistic effect has also been demonstrated for thymol and carvacrol. Furthermore, it has been demonstrated that sufficient doses of thymol and carvacrol have relaxant effects on trachea. Various clinical trials have confirmed the efficacy of thyme on productive cough. In a randomized double-blind clinical trial, 60 patients with productive cough were administered thyme syrup or bromhexine syrup for a period of 5 days. According to the patients' self-reports, there existed no significant difference between the two groups and both observed identical improvement by both of the medications. There was significant non-statistical progress in health of non-smokers compared to smokers in both groups.  
In a study to evaluate the antibacterial properties of the essential oil of Iranian Thyme against standard strains of golden Staphylococcus, Escherichia coli, Streptococcus pyogenes, Streptococcus pneumonia, Proteus mirabilis and Bacillus cereus, it was demonstrated that this essential oil has desirable antibacterial effect against the mentioned microorganisms. The amount of MIC was reported from 0.39 mg/ml to 1.56 mg/ml, and the golden Staph was more sensitive than the other assessed bacteria (0.39 mg/ml). Streptococcus pyogenes (1.56 mg/ml) and Proteus mirabilis (1.56 mg/ml) were the most resistant. In the cases of Streptococcus pneumonia, Escherichia coli and Bacillus cereus, an identical MIC equal to 0.7 mg/ml was registered. 
In a study of the chemical compounds and anti-staphylococcus activity of the essential oil of Iranian thyme and its synergistic effect with vancomycin, it was demonstrated that the main components of this essential oil are thymol (38.7%), carvacrol (15.3%) and p-cymene (10.2%) and its MIC and MBC against the resistant and sensitive strains of the golden Staph to methicillin isolated from the clinic was reported as 0.25-1 and 0.5-2 μl/ml, respectively, and the essential oil demonstrated synergistic effects with vancomycin.  The researchers came to the conclusion that Iranian thyme essential oil might be beneficial in control of infections caused by methicillin-resistant Staphylococcus aureus (MRSA).    
Commission E has approved the use of fennel for treatment of inflammation of mucus membranes in the upper respiratory tract. Fennel is expectorant and it enhances the mucociliary activity of the ciliated epithelium of the respiratory tracts. The chemical structure of the anethole present in fennel resembles that of catecholamines (adrenaline, noradrenaline and dopamine) and like adrenaline, fennel is a bronchodilator. In guinea pig, administration of fennel essential oil as inhaler caused mild antitussive or cough suppressant effects on coughs induced by mechanical stimulants. The antibacterial properties of fennel essential oil is determined as identical or more than the antibiotics streptopenicillin, penicillin and tetracycline.
Thyme and Fennel:
To evaluate the effects of thyme and fennel essential oils in treatment of cough, in a controlled, randomized, double-blind clinical trial, 119 patients of more than 14 years of age suffering from acute cough were administered three times per day, 20 drops Tussivin Oral Drop (containing sweet fennel and Iranian thyme essential oils), clobutinol drop or placebo for 3 days. At the end of this course, complete recovery was reported in the group receiving Tussivin Oral Drop and clobutinol as 50% and in the placebo group 9.1%. The efficacy of Tussivin Oral Drop, clobutinol and placebo in patients with productive cough was reported as 66.7%, 55% and 14.3%, respectively and 56.5%, 55% and 20% in patients with nonproductive cough. Regrading the degree of improvement of cough, significant difference was observed between Tussivin Oral Drop, clobutinol and placebo (p<0.01), but no significant difference was observed between Tussivin Oral Drop and clobutinol (p>0.4).
In another controlled, double-blind clinical trial, 62 patients with acute cough were randomly divided into two groups of Thymogel Oral Soft Capsule (containing essential oils of sweet fennel and Iranian thyme) or placebo, and were administered for 3 days, one soft capsule every 8 hours. After re-evaluation of the patients and gathering of data, the degree of recovery was calculated and to compare the treatment groups, chi-square test and Fisher's exact test were used. The results from this study showed that after 72 hours, total alleviation of cough had occurred in 62.5% of the patients in the Thymogel Oral Soft Capsule group and 20% of the patients in the placebo group (p=0.008). Considering the expectorant properties of fennel, alleviation of cough along with aiding of expectoration is a characteristic of Thymogel Oral Soft Capsule.
  • Existence of severe hypersensitivity (allergy) to essential oil of Iranian thyme or fennel or the other ingredients of the product
  • Pregnancy and lactation
  • Menstruation period
  • Allergic asthma
  • Children under 2 years of age
Adverse Effects
Seldom photodermatitis, vertigo, headache, nausea and vomiting have been reported in cases of administration beyond the recommended dosage.The thymol in the product might irritate mucus membranes. In case of overdose, occurrence of seizure is probable.
In case any of these adverse reactions, or any other adverse reactions occur, it is recommended to consult your physician or pharmacist.
Interactions No reported interaction.
  • Not to be taken during pregnancy and lactation.
  • Keep Thymogel Oral Soft Capsule, like all other medication, away from sight and reach of children.
  • Keep the medicine away from light and in 15-30°C.
  • Do not use the drug after expiration date.
  • Keep this leaflet; you may need to read it again.

  • ISO 17025
  • IR GMP
  • ISO 9001
  • I.R.I.FDO
  • ISO 10004
  • ISO 10668

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Tags: Acute Cough Treatment Soft Capsule/Acute Cough Treatment Soft/Capsule